What is the generally recommended rest period between sets for hypertrophy training?

The generally recommended rest period between sets for hypertrophy training is 30-60 seconds. This specific rest duration is effective for maximizing muscle growth because it strikes a balance between allowing enough recovery for subsequent sets while still maintaining a metabolic stress that is conducive to hypertrophy. Shorter rest periods, such as 15-30 seconds, may not provide sufficient recovery for higher-volume or intensity training sessions where heavier loads are being utilized.

Longer rest periods, such as 2-3 minutes, are typically more appropriate for strength training, where complete recovery is necessary to execute maximal or near-maximal lifts. While rest periods of 1-2 minutes can be beneficial, they may not optimize the metabolic stress related to hypertrophy as effectively as the 30-60 seconds range, which is specifically tailored to enhance muscle fatigue and the hormonal response needed for growth.